^ Never say never.
Cincinnati Bearcats lost to Oklahoma in their second game of the season 52 to 26. In the game, our star starting quarterback Dustin Grutza broke his foot, which was believed at the time to be the downfall of Brian Kelly's spread offense.
Tony Pike became the starting quarterback, an unknown Cincy native, who turned out to be one of the best quarterbacks in college football that year. Even Pike got injured during an Akron matchup, breaking his forearm, which forced us to even lean further back on our #3 quarterback Chaz Anderson and #4 quarterback Zach Collaros. The above video I posted was Zach's first play as a Bearcat during the 2008 season.
Bearcats ultimately went 11-2, and saw their first ever BCS appearance at the Orange Bowl.
While moments in the season seemed to be bowl-hope enders, the team was able to turn around with amazing results.